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【请教】氯硝西泮和米氮平可以合用吗

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推荐AstraZeneca资助的一组临床实用网站

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  • weioncol
    weioncol  发布了新帖 资讯翻译 Pembrolizumab和化疗联用治疗鳞状小细胞肺癌 21天前

    Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung CancerN Engl J Med. 2018 Nov 22;379(21):2040-2051. doi: 10.1056/NEJMoa1810865. Epub 2018 Sep 25.AbstractBACKGROUND:Standard first-line therapy for metastatic, squamous non-small-cell lung cancer (NSCLC) is platinum-based chemotherapy or pembrolizumab (for patients with programmed deat

  • weioncol
    weioncol  回复了帖子  Nab-Paclitaxel和Atezolizumab联用治疗转移性三阴乳癌1b临床试验2年随访 44天前
    几点个人意见,未必算改错,或许只是另一种表述方式, 供参考。1笔误:JAMA Oncol. 不是 “新英格兰医学杂志”,而是“美国医学会杂志 肿瘤学子刊”(或“肿瘤学分册??”2The primary end point was safety and tolerability. Secondary end points included best overall response rate by Response Evaluation Criteria in Solid Tumors, version 1.1; objective response rate; duration of response; disease control rate; progression-free survi
  • weioncol
    weioncol  回复了帖子 Atezolizumab和Nab-Paclitaxel联用治疗晚期三阴性乳腺癌 44天前
    译文专业、老道,中文表述不俗,难得! 学习中……一点小意见共参考In this phase 3 trial, we randomly assigned (in a 1:1 ratio) patients with untreated metastatic triple-negative breast cancer to receive atezolizumab plus nab-paclitaxel or placebo plus nab-paclitaxel; ……原译文在这项III期试验中,我们将无法治疗的三阴性乳腺癌患者随机分配(按1:1的比例)接受阿特珠单抗联合白蛋白结合型紫杉醇方案或安慰剂联合白蛋白结合型紫杉醇治疗;……建议译文在这项III期试验中,我们将初治的三阴性乳腺癌患者随机
  • weioncol
    weioncol  发布了新帖 Atezolizumab治疗转移性三阴乳癌1期临床试验长期临床转归及生物标志物分析 47天前

    Abstract [JAMA Oncol. 2018 Sep 13. [Epub ahead of print]Importance:Atezolizumab (anti-programmed cell death ligand 1 [PD-L1]) is well tolerated and clinically active in multiple cancer types. Its safety and clinical activity in metastatic triple-negative breast cancer (mTNBC) has not been reported.Objective:To evaluate the safety, clinical activity

  • weioncol
    weioncol  发布了新帖 Nab-Paclitaxel和Atezolizumab联用治疗转移性三阴乳癌1b临床试验2年随访 47天前

    AbstractImportance:The humanized monoclonal antibody atezolizumab targets programmed death-ligand 1 and has demonstrated durable single-agent activity in a subset of metastatic triple-negative breast cancers. To extend the observed activity, combinatorial approaches are being tested with standard cytotoxic chemotherapies known to induce immunogenic

  • weioncol
    weioncol  发布了新帖 Atezolizumab和Nab-Paclitaxel联用治疗晚期三阴性乳腺癌 47天前

    Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast CancerN Engl J Med. 2018 Oct 20. doi: 10.1056/NEJMoa1809615. [Epub ahead of print]AbstractBACKGROUND:Unresectable locally advanced or metastatic triple-negative (hormone-receptor-negative and human epidermal growth factor receptor 2 [HER2]-negative) breast cancer is an aggressive di

  • weioncol
    weioncol  发布了新帖 一项美国大型成人研究显示饮酒与人口腔菌群变异相关 64天前

    Drinking alcohol is associated with variation in the human oral microbiome in a large study of American adults.AbstractBACKGROUND:Dysbiosis of the oral microbiome can lead to local oral disease and potentially to cancers of the head, neck, and digestive tract. However, little is known regarding exogenous factors contributing to such microbial imbal

  • weioncol
    weioncol  发布了新帖 服用阿司匹林与肝细胞癌风险之间的相关性 66天前

    Association Between Aspirin Use and Risk of Hepatocellular CarcinomaAbstractImportance:Prospective data on the risk of hepatocellular carcinoma (HCC) according to dose and duration of aspirin therapy are limited.Objective:To examine the potential benefits of aspirin use for primary HCC prevention at a range of doses and durations of use within 2 pr

  • weioncol
    weioncol  回复了帖子 阿昔替尼和克唑替尼一线治疗ALK阳性NSCLC之比较 72天前
    译文专业、流畅,中文表述尤其不俗,难得,学习中……参与校对修改,几处小商榷,个人意见,仅供参考。不一定算纠错,有时仅只是提供另一种中文可读性1In 2011, crizotinib (Xalkori) became the first effective targeted therapy for anaplastic lymphoma kinase (ALK)-positive non–small cell lung cancer (NSCLC). Now data from a phase III trial show that alectinib (Alecensa), a second-generation ALK inhibitor, outperfor
  • weioncol
    weioncol  回复了帖子 阿昔替尼和克唑替尼一线治疗ALK阳性NSCLC之比较 72天前
    阿昔替尼和阿来替尼阿昔替尼http://dxy.me/TTYoXV 英立达Inlyta(阿昔替尼片axitinib),是由世界制药巨头辉瑞(Pfizer)公司研发的新一代肾癌靶向治疗药物(酪氨酸激酶抑制剂TKI),2015年4月29日获得CFDA批准。在国内,英立达主要用于既往细胞因子相关治疗方案(白介素-2、干扰素-α、肾癌疫苗、自体免疫细胞治疗DC-CIK等)失败的成人进展期肾癌患者;也可用于既往抗血管生成治疗药物(多靶点酪氨酸激酶抑制剂)失败(进展、无法耐受、肿瘤抑制程度弱等)的晚期肾癌患者。阿昔替尼目前在多国上市(包括美国、欧洲、加拿大、澳大利亚、韩国、日本等),已成为晚期肾癌的标准治疗方案之一
  • weioncol
    weioncol  回复了帖子 肠道菌群与老年病的关联 82天前
    "研究者将来自老年老鼠的肠道细菌植入年轻老鼠中……"“老鼠”是生活用语,不是专业用语、学术用语,建议改为“小鼠”研究者将老年小鼠的肠道细菌植入年轻小鼠中……
  • weioncol
    weioncol  发布了新帖 关于防止中风复发的最佳LDL胆固醇水平当低于100 mg/dL的研究 138天前

    LDL Cholesterol Below 100 mg/dL Optimal for Preventing Stroke Recurrence: StudyBy Will Boggs MDApril 02, 2018https://www.medscape.com/viewarticle/894641?src=wnl_edit_tpal&uac=97756AZ NEW YORK (Reuters Health) - The optimal LDL-cholesterol level for preventing stroke recurrence appears to be between 80 and 100 mg/dL, researchers from Japan repor

  • weioncol
    weioncol  回复了帖子 上医的医学生有可能比肩甚至赶超北医协和的医学生吗? 147天前
    复旦的上医原先是上海第一医学院,原即为部属全国重点院校;上交的医学院前身是上海第二医学院,原属上海地方管(当然上海一向傲视全国,牛逼的很……)。至少,总体实力不能说复旦的上医弱于上交。当然,上交的一些医院很牛逼,如瑞金,原先的广慈医院……。赞同上面学长的意见,复旦的上医和协和同属第一梯队,不要妄自菲薄,关键是提升自身实力,注意跟上自己喜欢的专业(这个非常重要!!!但不必现在就最后确定)一个大牛博导……原先的经典说法是“北协和,南湘雅”,这是几十年(尤其49年以前)国人普遍认可的说法。两者都是美国人在华办学,有很多相似之处,牛逼的程度相近,只是湘雅地处内地,地缘优势比不上首都北京(和原先的北平),且49年后受极左政治冲击较多……。湘雅1914年建校,湘雅第四届学生,入学60人,毕业4人,可见其
  • weioncol
    weioncol  回复了帖子 医学科研思维与论文撰写—王福彦 杜茂林 主编2015.4出版 173天前
    很好的内容,可总是提示出错,无法解压。可否请楼主再发一次?谢谢了!!
  • weioncol
    weioncol  的帖子被加了1分 186天前

    回复:【资讯翻译】癌症死亡率降低,但晚期前列腺癌发病率却节节攀升

    译文专业流畅,中文功底尤其不俗,难得,学习中……参与校对修改,几处小商榷,个人意见,仅供参考。不一定算纠错,有时仅只是提供另一种中文可读性篇幅大,辛苦了!1The "most notable exceptions" to the decline are ute...
  • weioncol
    weioncol  回复了帖子 癌症死亡率降低,但晚期前列腺癌发病率却节节攀升 188天前
    译文专业流畅,中文功底尤其不俗,难得,学习中……参与校对修改,几处小商榷,个人意见,仅供参考。不一定算纠错,有时仅只是提供另一种中文可读性篇幅大,辛苦了!1The "most notable exceptions" to the decline are uterine cancer and liver cancer in both men and women, say Kathleen A. Cronin, PhD, MPH, of the Division of Cancer Control and Population Sciences at the National Cancer Institute (NCI) in Bethesda, Maryland, and
  • weioncol
    weioncol  发布了新帖 癌症死亡率降低,但晚期前列腺癌发病率却节节攀升 201天前

    Cancer Deaths Falling, but Uptick in Late-Stage Prostate Cahttps://www.medscape.com/viewarticle/897096?src=WNL_infoc_180527_MSCPEDIT_onc&uac=97756AZ&impID=1641455&faf=1  The number of deaths due to cancer in the United States is continuing to decline in men, women, and children across all major racial and ethnic groups, according t

  • weioncol
    weioncol  发布了新帖 培训一线人员处理CAR-T疗法的毒性至关重要 217天前

    Training 'Front-line' Staff to Manage CAR T Toxicity Is CriticalTheodore BosworthApril 26, 2018https://www.medscape.com/viewarticle/895528?nlid=122106_485&src=WNL_mdplsfeat_180508_mscpedit_honc&uac=97756AZ&spon=7&impID=1627369&faf=1 For centers considering a chimeric antigen receptor (CAR) T-cell program, training nurs

  • weioncol
    weioncol  发布了新帖 T细胞生物标志物预示CAT细胞疗法对慢淋的疗效 217天前

    T-Cell Biomarker Predicts Response to CAR T-Cell Therapy in Patients With CLLRoxanne Nelson, BSN, RNMay 07, 2018https://www.medscape.com/viewarticle/896261?nlid=122106_485&src=WNL_mdplsfeat_180508_mscpedit_honc Chimeric antigen receptor (CAR) T-cell therapy has been hailed as one of the great advances in oncology care, but not all pat

  • weioncol
    weioncol  回复了帖子 丁香园版主/助理版主请销假备案处 218天前
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